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"Increased waist circumference is the single most important predictor of Metabolic Syndrome" The Zerona low level LASER device has been clinically validated and US-FDA cleared to reduce the circumference of the waist, hips and thighs. Zerona modulates subcutaneous fat adipocytes causing the reduction of adipocyte mass due to the release of stored intracellular fatty material.

In 2008, a clinical trial involving 67 subjects,out of which 35 were randomly assigned to receive Zerona treatment with 32 assigned for the control group. A total of 6 treatments were given to the patients every alternate day for two weeks.

The study showed noticeable reduction in the circumference of the waist, hips and thighs.

In two weeks the overall circumferential measurements are reduced and the debris is safely absorbed and mobilized by the lymphatic and circulatory system. Adipose tissue (AT) is defined as: "An endocrine organ responsible for the synthesis of bioactive peptides which participate in autocrine, paracrine and endocrine pathways. Furthermore, AT is composed of a vibrant collection of cells including fibroblast, pre-adipocytes, adipocytes, immune cells, and a variety of other cells all embedded within the framework of connective tissue. It is believed that several adipose derived bioactive substances are released through a coordinated fashion with other cells located in AT utilizing paracrine or autocrine pathways."The diverse collection of cytokines and bioactive molecules (adipokines) secreted by AT have been shown to change lipid metabolism, insulin sensitivity, and blood pressure. Structural modifications are seen in an individual classified as overweight or Obese before excessive nutrient consumption.The onset of diabetes, hypertension and cardiovascular diseases are a result of the release of noxious adipokines causing expansion in adipose mass and volume. Adipocytes function and behavior is directly related to its mass.

Following a period of excessive nutrient consumption, adipocytes become enlarged.

Adipocyte expansion is believed to interrupt the cell function, yielding pathological consequences. Adipocyte hypertrophy has been shown to directly disrupt angiogenesis, adipogenesis, ECM dissolution and reformation, lipogenesis, Growth factor production, Glucose metabolism, Lipid metabolism, Enzyme production, Immune response and hormone reduction. Furthermore it has been shown by studies that an alteration in gene expression reporting an up regulation in pro-inflammatory factors promotes the onset of metabolic disorders like atherosclerosis.AT communicates with multiple body systems that include nervous, Immune, Skeletal, Cardiovascular and gastro-intestinal system Participating in paracrine and autocrine signaling, adipocytes impairment which may account for metabolic dysfunction. Adipocyte hypertrophy affects AT function increasing the patient's risk of developing serious metabolic disorders.Adipocytes release beneficial hormones and bio active substances that can prevent insulin resistance, diabetes and atherosclerosis.Immediate reduction of the adipocytes mass is necessary to restore proper cell function and behavior.

The Zerona, may serve as a viable therapy for adipocytes volume reduction without destruction leading to the reduction of subcutaneous fat volume.The adipocytes destructive procedures are not advisable as these procedures devoid the body from physiological/endocrine/regulatory roles of adipocytes. Proper adipocytes function can be reestablished by a reduction in adipocytes cell volume can potentially triggering production of valuable bioactive substances.A series of blood analysis were conducted to elucidate the medical utility of Zerona which included the assessment of post therapy levels of serum cholesterol, Triglycerides, LDL, HDL and Leptin.Leptin represents adipocytes derived cytokine believed to function as a 'Starvation signal', slowing the metabolic rate and modulating hormone levels.Plasma Leptin levels are found elevated in patients with larger fat mass compared to patients to the patients with the smaller mass.Loss of Leptin sensitivity dampens mechanisms that regulate hunger and metabolic metabolism increasing the risk of obesity.Following a 2 week series of 6 Zerona treatments, patients Leptin levels were significantly lower compared to baseline. Excessive adipose tissue mass deregulates at function having deleterious endocrinologic and immunologic effects.

Zerona has earned FDA clearance as a safe and effective therapeutic device for the reduction of adipose mass in the waist, hips and thighs.The cosmetic slimming induced by Zerona represents a limited benefit as the device may serve as an effective means for promoting the release of anti-diabetic and anti-atherosclerotic adipokines.

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